College Football Week 8 brings a slate built around five games that carry both conference stakes and postseason implications. Odds from DraftKings Sportsbook as of Oct. 22 frame each matchup, and Week 7 results have shifted several teams’ standing. Indiana lost for the first time since 2024. BYU climbed to No. 2 after an upset of Notre Dame. Texas dropped a second straight game. Utah reached 6-0 for the first time in 12 years. Below is a look at the spreads, moneylines and totals for the five highlighted games, plus the analysis and expert picks attached to each.
Indiana vs Michigan
Indiana is a 7.5-point favorite with a moneyline of -278 and an over/under of 41.5. Michigan is +225 on the moneyline. The Hoosiers are 6-1 straight up but just 1-6 against the spread. Michigan is 4-2 straight up and 2-4 against the spread, including a controversial 13-12 season-opening win over Western Michigan.
Indiana’s first loss since 2024 came in Week 7, a 19-15 decision against Ohio State. The Hoosiers have not lost consecutive games under coach Curt Cignetti. Laken Litman expects that streak to hold, picking Indiana to avoid a second straight defeat. Indiana also carries +750 College Football Playoff odds.
BYU vs UCF
BYU is favored by 6.5 points with a -258 moneyline and an over/under of 43.5. UCF is +210 on the moneyline and 4-2 against the spread while sitting 3-3 straight up. The Cougars are ranked No. 2 nationally after a 28-24 upset of Notre Dame in Week 7, an emotional win that lifted them into the top tier of the rankings.
Despite the No. 2 ranking, BYU is listed at +4400 to win the national title. That number suggests the market remains skeptical of the Cougars’ championship case even as their résumé has strengthened.
UCLA vs Michigan State
UCLA is a 14.5-point favorite with a -700 moneyline and an over/under of 43.5. Michigan State is +500 on the moneyline, 2-5 straight up and 4-2-1 against the spread. The Bruins are 6-0 under first-year coach Bob Chesney, but they are without their starting quarterback.
Backup Ty Dieffenbach started Week 7 against Wisconsin and passed 22 of 33 for 264 yards. His first start produced enough for UCLA to remain undefeated, and the Bruins are now tasked with covering a two-touchdown spread with him under center.
Texas vs Ole Miss
Texas is a 3.5-point favorite with a -162 moneyline and an over/under of 54.5. Ole Miss is +136 on the moneyline. The Longhorns are 4-2 straight up but 1-5 against the spread after consecutive losses to Oklahoma and Florida. Texas is +135 to make the 12-team playoff, a price that reflects how quickly its position has changed.
Ole Miss beat Missouri 31-3 in Week 7 behind Trinidad Chambliss, who passed for 241 yards and three touchdowns. Joel Klatt predicts Ole Miss will win outright 28-21 and cover the 3.5-point spread.
Utah vs Houston
Utah is a 6.5-point favorite with a -250 moneyline and an over/under of 56.5. Houston is +205 on the moneyline. The Utes are 6-0 overall and in the top 10, their best start in 12 years. Quarterback Devon Dampier passed for 278 yards and three touchdowns in a 27-24 win over Colorado, a game in which Utah totaled 409 yards.
Houston is 6-1 overall after beating Oklahoma State 35-32 in Week 7. Connor Weigman threw for 343 yards and five touchdowns in that win. Ben Portnoy backs Houston, citing the momentum from the Oklahoma State victory under coach Willie Fritz.
What the numbers say
The five games offer a mix of large favorites and tighter spreads. UCLA’s -14.5 line is the widest of the group, while Texas’s -3.5 is the narrowest. Indiana, BYU and Utah are all favored by roughly a touchdown. The moneylines range from UCLA’s -700 to Michigan State’s +500.
Against-the-spread records add another layer. Indiana’s 1-6 mark and Texas’s 1-5 mark stand out against their straight-up success. Michigan State’s 4-2-1 ATS record and UCF’s 4-2 mark suggest those underdogs have been more reliable for spread bettors than their outright results indicate.
Expert picks to watch
Litman’s pick rests on Cignetti’s streak of avoiding consecutive losses at Indiana. Klatt’s prediction calls for Ole Miss to win outright and cover against Texas. Portnoy’s selection leans on Houston’s momentum after a high-scoring Week 7 win. The outcomes will be settled on the field, but the reasoning behind each pick ties directly to recent results and established patterns.
